| 维生素B6与苯巴比妥的相互作用 |
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| 引用本文： | 胡朝欣,陈湛芳,单若冰,张玉华,王志燕. 维生素B6与苯巴比妥的相互作用[J]. 儿科药学杂志, 2002, 8(1): 32-33 |
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| 作者姓名： | 胡朝欣 陈湛芳 单若冰 张玉华 王志燕 |
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| 作者单位： | 青岛市儿童医院儿研所,青岛,266011;青岛市儿童医院新生儿科,青岛,266011 |
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| 摘 要： | 目的:探讨大剂量维生素B6与苯巴比妥的相互作用。方法:分析两例新生儿合并使用大剂量维生素B6后其苯巴比妥血药浓度代谢速度与群体药动学参数的差异。结果:患者苯巴比妥血药浓度代谢速度较群体代谢速度快近一倍。结论:大剂量维生素B6可加快苯巴比妥的代谢速度。
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| 关 键 词： | 维生素B6 苯巴比妥 药物相互作用 |
| 文章编号： | 1009-6884(2002)01-0032-02 |
| 修稿时间： | 2001-06-04 |
The interactions between pyridoxine and phenobarbital |
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| HU Chaoxin,CHEN Zhanfang,SHAN Ruobing,ZHANG Yuhua,WANG Zhiyan. The interactions between pyridoxine and phenobarbital[J]. Journal of Pediatric Pharmacy, 2002, 8(1): 32-33 |
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| Authors: | HU Chaoxin CHEN Zhanfang SHAN Ruobing ZHANG Yuhua WANG Zhiyan |
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| Affiliation: | HU Chaoxin1,CHEN Zhanfang1,SHAN Ruobing2,ZHANG Yuhua2,WANG Zhiyan1 |
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| Abstract: | Objective: To study the interactions between pyridoxine and phenobarbital. Method: The pharmacokinetics of phenobarbital in two newborn infant during administrating large dosage of pyridoxine were compared with the population pharmacokinetics. Results:The metabolic rate of phenobarbital in the two patients were almost as twice as that of the population. Conclusion:Large dosage of pyridoxine accelarate the metabolic rate of phenobarbital. |
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| Keywords: | Pyridoxine Phenobarbital Interaction |
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