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| 血液透析及血液透析滤过对尿毒症患者P300影响的研究 | |
| 引用本文： | 李涛,何晓阔,张建鄂,张庆红,罗昌霞,吴平勇,王顺华. 血液透析及血液透析滤过对尿毒症患者P300影响的研究[J]. 中国血液净化, 2009, 8(1) |
| 作者姓名： | 李涛 何晓阔 张建鄂 张庆红 罗昌霞 吴平勇 王顺华 |
| 作者单位： | 1. 442000十堰,湖北郧阳医学院附属十堰市太和医院,肾内科 2. 442000十堰,湖北郧阳医学院附属十堰市太和医院,神经内科 |
| 摘 要： | 目的通过事件相关电位P300探讨尿毒症患者认知功能,以及血液透析、血液透析滤过对尿毒症患者认知功能的影响。方法52例尿毒症患者随机分为血液透析组31例,血液透析滤过组21例,分别接受血液透析、血液透析滤过治疗1月,测定两组患者治疗前后P300,以同期健康体检者作对照。结果①尿毒症患者P300异常率为86.6%,高于健康对照组,表现为P300潜伏期延长,波幅降低;②血液透析及血液透析滤过组患者治疗后P300的异常率较治疗前明显下降,同治疗前比较,潜伏期缩短,波幅增高,上述改变血液透析滤过组较血液透析组更明显。结论慢性肾衰竭尿毒症患者认知功能障碍发生率高,血液净化可以明显改善尿毒症患者的认知功能,血液透析滤过优于血液透析。 |
| 关 键 词： | 尿毒症 认知功能 P300 血液透析 血液透析滤过 |
The effect of hemodialysis and hemodlafiltration on event-related potentials P300 in uremic patients |
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| LI Tao,HE Xiao-kuo,ZHANG Jian-e,ZHANG Qing-hong,LUO Chang-xia,WU Pin-yong,WANG Shun-hua. The effect of hemodialysis and hemodlafiltration on event-related potentials P300 in uremic patients[J]. Chinese Journal of Blood Purification, 2009, 8(1) | |
| Authors: | LI Tao HE Xiao-kuo ZHANG Jian-e ZHANG Qing-hong LUO Chang-xia WU Pin-yong WANG Shun-hua |
| Affiliation: | 1De-partment of Nephrology; 2Department of Neurology; Taihe Hospital Affiliated to Yunyang Medical College; Shiyan; Hubei 442000; China; |
| Abstract: | Objective To study cognition function in uremic patients and the changes of cognition func-tion after hemodialysis and hemodiafiltration by examination of event-related potentials P300. Methods P300 was determined in 31 patients treated with hemodialysis,21 patients treated with heomdiafiltration and 49 normal controls. Results P300 was abnormal in 86.6% uremic patients. The P300 demonstrated prolonged latency and decreased amplitude as compared with those of the control group. Conclusions Cognition functio... |
| Keywords: | P300 |
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