肾病综合征患者中血清铁与载脂蛋白AI和载脂蛋白B的相关性分析

目的探讨肾病综合征患者血清铁与载脂蛋白AI和载脂蛋白B之间的关系。方法分别用比色法检测正常对照组和肾病综合征组血清铁以及血脂（总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇）水平，用免疫比浊法检测载脂蛋白AI、载脂蛋白B和脂蛋白（a）。结果对照组与肾病综合征组间，除血清铁差异无统计学意义外（P〉0．05），其余血脂各项指标差别均有统计学意义（P〈0．01）。对照组中，血清铁与脂蛋白（a）具有相关关系（r=0．277，P〈0．05），差异有统计学意义；肾病综合征组中血清铁与载脂蛋白AI（r=0．628，P〈0．01）和载脂蛋白B（r=0．48，P〈0．05）具有相关性，差异有统计学意义外，与其余诸项血脂指标无相关性，差异无统计学意义。结论肾病综合征患者中血清铁的水平可能与载脂蛋白AI和载脂蛋白B的紊乱有关系，其生物学意义尚待进一步研究。

Association between sera iron and apoAI, apoB in nephritic syndrome

Objective To study the association between sent Iron(SI) levels and sera apolipoprotein(Apo) AI, ApoB levels in Nephritic Syndrome (NS). Methods SI, Total Cholesterol(Tc),Triglycerides(TG),High Density Lipoproteirm Cholesterol(HDL-C) and Low Density Lipoproteins Cholesterol (LDL-C) were measured with colorimetry and Lipoprotein(a) (Lp (a)), ApoAI and ApoB with immune-turbidimetry in NS patients and normal subjects served as controls. Results Significant positive linear correlations were found between SI and ApoAI (r= 0.628, P < 0.01), and ApoB (r = 0.48, P < 0. 05) respectively, while no significant linear correlations were found between SI and another test [for example, Tc, TG, HDL-C, LDL-C and LP (a)] (P>0.05). No significant linear correlations were found between SI and others sera lipids (P> 0. 05) , but LP(a) (r=0.277, P < 0.05) in normal subjects. Condusion SI may be associated with the ApoAI and ApoB in NS, but the biological significance among them need study furtherly.