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Measurement of oxidative stress and antioxidant status in acute lymphoblastic leukemia patients |
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| Authors: | Battisti Vanessa Maders Liési D K Bagatini Margarete D Santos Karen F Spanevello Rosélia M Maldonado Paula A Brulé Alice O Araújo Maria do Carmo Schetinger Maria R C Morsch Vera M |
| Affiliation: | aDepartamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus Universitário, 97105-900 Santa Maria, RS, Brazil bDepartamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcellos, 2600-Anexo, 90035-003, Porto Alegre, RS, Brazil cHospital Universitário de Santa Maria-HUSM, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil |
| Abstract: | ObjectivesTo evaluate the oxidative status and antioxidant defense in patients with acute lymphoblastic leukemia (ALL).Design and methodsWe measured concentrations of plasmatic thiobarbituric acid reactive substances (TBARS), serum protein carbonylation, whole blood catalase (CAT) and superoxide dismutase (SOD) activities, as well as the plasmatic and erythrocyte thiol levels and serum vitamin E concentration. This study was performed on 80 children with ALL divided into 4 groups: just diagnosed, remission induction, remission maintenance and out-of-treatment.ResultsTBARS levels and serum protein carbonylation were higher in ALL patients than in controls and reduced levels of antioxidants were found in these patients.ConclusionThese findings may indicate a possible link between decreased antioxidants and increased levels of cells alterations due to oxidative damage, supporting the idea that there is a persistence of oxidative stress in acute lymphoblastic leukemia. |
| Keywords: | Acute lymphoblastic leukemia (ALL) Oxidative stress Antioxidant system TBARS Protein carbonylation SOD CAT Thiols Vitamin E |
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