中药活性成分对卵巢癌的直接作用机制研究进展

卵巢癌在女性生殖器官恶性肿瘤中的发生率及病死率均较高，传统的治疗手段包括手术治疗、化学药物治疗（化疗）、放射线治疗及上述治疗方式的联合应用。近年来发现我国传统中药成分如金雀黄素、薏苡仁、植物固醇类、姜黄素、五羟黄酮、人参皂苷等可在体内和（或）体外发挥对卵巢癌细胞的抑制增殖、诱导凋亡、增加对化疗药物的敏感性等抗癌作用。其作用机制涉及到抑制细胞代谢关键酶活性、影响细胞基因表达、抗氧化、抑制肿瘤新生血管形成等方面，其作为卵巢癌的一种辅助治疗手段，有着广阔的临床应用前景。

Progress on the Study of Mechanism of the Direct Action of TCM Bioactive Components on Ovarian Cancer

Both the morbidity and mortality of ovarian cancer, among malignant tumors of female genital organs, are quite high. The traditional therapeutic methods on ovarian cancer are surgical operation, chemotherapy, radiotherapy and combination of these methods mentioned above. In recent years, some components of traditional Chinese medicine, such as genistein, semen Coicis, phytosterols, curcumin, quercetin, ginsenoside, etc. have been found to exert anticancer actions of inhibiting proliferation and inducing apoptosis of cancer cells,increasing the sensitivity of patients to chemotherapeutic agents in vivo and/or in vitro, the mechanisms involve such aspects as inhibiting activity of key enzymes in cell metabolism, affecting gene expression, antioxidation, and inhibiting tumor angiogenesis, etc, As an adjuvant therapeutic means, the bioactive components of traditional Chinese Medicine have broad future of clinical application.