Blocking Effect of Rheumatoid Factor on the In Vitro Cytotoxicity of Lymphoid Cells from Carcinoma Patients |
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| Authors: | E. SAKSELA,S. PYRHö NEN,T. TIMONEN,A.-M. TEPPO,O. WAGER,K. PENTTINEN |
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| Affiliation: | Third Department of Pathology and Department of Virology, University of Helsinki;The Municipal Bacteriological Laboratory, Aurora Hospital;and Laboratory of Pathology, I-II Department of Obstetrics and Gynecology, University Central Hospital;Helsinki, Finland |
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| Abstract: | ![]()
Human cryo-IgM rheumatoid factor (RF) preparations blocked the tumor-specific in vitro cytotoxicity of ovarian or bladder carcinoma patients' lymphoid cells in microcytotoxicity assays. The effect was mediated by pretreatment of the effector cells. Cryo-IgM RF free of detectable IgG blocked in a dilution-dependent manner, and immunosorbent purification of contaminating IgG from another preparation did not abrogate the blocking effect. Control IgM preparations lacking RF activity did not block the cytotoxicity, and normal human serum preincubation of the RF preparations rendered them inactive, indicating that the blocking effect was due to the anti-IgG activity of the RF. |
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