Sesquiterpene dimmer (DSF-27) inhibits the release of neuroinflammatory mediators from microglia by targeting spleen tyrosine kinase (Syk) and Janus kinase 2 (Jak2): Two major non-receptor tyrosine signaling proteins involved in inflammatory events |
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| Authors: | Ke-Wu Zeng Shu Wang Xin Dong Yong Jiang Hong-Wei Jin Peng-Fei Tu |
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| Affiliation: | 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China;2. Department of Medicinal Chemistry and Pharmaceutical Analysis, Logistics College of Chinese People''s Armed Police Forces, Tianjin 300162, China |
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| Abstract: | |
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| Keywords: | NRPTKs, non-receptor protein tyrosine kinases Jak2, Janus kinase 2 LPS, lipopolysaccharide IL-6, interleukin-6 IL-1β, interleukin-1β TNF-α, tumor necrosis factor-α NO, nitric oxide PIAS, protein inhibitors of activated STAT IKK, IκB kinase NF-κB, nuclear factor kappa-B |
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