|
|||||
|
|
Availability of human induced pluripotent stem cell-derived cardiomyocytes in assessment of drug potential for QT prolongation |
|
| Authors: | Yumiko Nozaki Yayoi Honda Shinji Tsujimoto Hitoshi Watanabe Takeshi Kunimatsu Hitoshi Funabashi |
| Affiliation: | 1. Preclinical Research Laboratories, Dainippon Sumitomo Pharma. Co., Ltd., Suita, Osaka 564-0053, Japan;2. Regenerative & Cellular Medicine Office, Dainippon Sumitomo Pharma. Co., Ltd., Chuo-ku, Tokyo 104-0031, Japan |
| Abstract: | Field potential duration (FPD) in human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), which can express QT interval in an electrocardiogram, is reported to be a useful tool to predict K+ channel and Ca2 + channel blocker effects on QT interval. However, there is no report showing that this technique can be used to predict multichannel blocker potential for QT prolongation. The aim of this study is to show that FPD from MEA (Multielectrode array) of hiPS-CMs can detect QT prolongation induced by multichannel blockers. |
| Keywords: | Early afterdepolarization (EAD) Field potential duration (FPD) Human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) Multielectrode array (MEA) QT prolongation Torsade de Pointes (TdP) |
| 本文献已被 ScienceDirect 等数据库收录！ | |