Repeated Nrf2 stimulation using sulforaphane protects fibroblasts from ionizing radiation |
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| Authors: | Sherin T. Mathew,Petra Bergströ mOla Hammarsten |
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| Affiliation: | Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden |
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| Abstract: | |
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| Keywords: | AP, apurinic/apyramidinic ARE, antioxidant response element CM- H2DCFDA, 5-(and-6) chloromethyl-2&prime ,7&prime dichlorodihydrofluorescein diacetate DSBs, double-strand breaks EdU, 5-ethynyl-2&prime -deoxyuridine GST, glutathione transferase HO1, heme oxygenase1 Keap1, kelch-like ECH-associated protein 1 MEF, mouse embryonic fibroblasts NQO1, NAD(P)H:quinone oxidoreductase 1 Nrf2, nuclear factor-erythroid-2-related factor 2 ROS, reactive oxygen species SSBs, single-strand breaks tBHQ, tert-butylhydroquinone |
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