海洛因成瘾者大脑突显性网络异常的独立成分分析

目的探讨海洛因成瘾者大脑突显性网络的变化特征。材料与方法 26例海洛因成瘾者与39例年龄、性别、教育程度相匹配的健康被试参加本静息态功能性磁共振成像(functional magnetic resonance imaging,f MRI)研究数据处理,运用独立成分分析方法对影像数据提取突显性网络,比较该网络功能连接的差异,探讨差异脑区功能连接与海洛因吸食史的相关性。结果与正常组相比,海洛因成瘾者大脑左侧岛叶功能连接显著性增强,且与海洛因食用剂量成正相关(P=0.02,r=0.46)。结论长期吸食海洛因的成瘾者突显性网络功能连接异常增强,突显性网络在海洛因成瘾过程中发挥重要作用。

The abnormal salience network of the brain in heroin addicts: A resting-state functional magnetic resonance image study based on independent component analysis

Objective: To investigate the characteristics of the salience network in heroin addicts. Materials and Methods: Twenty-six heroin addicts and thirty-nine healthy controls were enrolled in the resting-state functional magnetic resonance imaging scan. Independent component analysis was used to identify the salience network from the image data, the difference in strength of functional connectivity within the core brain areas of salience network between the two groups was analyzed, then the relationship between total heroin consumption and strength of connectivity of differential regions was analyzed. Results: Compared with the healthy controls, the functional connectivity of the left insula was significantly greater in the heroin addicts. And the functional connectivity of insula was positively correlated with the heroin consumption (P=0.02, r=0.46). Conclusion: Long-term heroin use results in abnormally increased functional connectivity of salience network in heroin addicts. The salience network plays a key role in heroin addicitoin.