孕母慢性淋巴细胞性甲状腺炎对婴儿智能发育的影响

目的：探讨孕母患慢性淋巴细胞性甲状腺炎对婴儿的影响。方法：通过浙江省新生儿疾病筛查网络系统，从2001年7月至2003年6月对21例母亲患慢性淋巴细胞性甲状腺炎的婴儿进行随访，观察其甲状腺功能情况，并采用Gesell发育量表对其智能发育进行跟踪调查。结果：21例婴儿中甲状腺功能正常8例，高TSH血症11例，先天性甲低2例，与同期健康母亲的新生儿相比差异有显著性（P〈0．01）；孕母患慢性淋巴细胞性甲状腺炎的婴儿其应物能、应人能、粗动作能、细动作能发育均落后，与健康孕母的婴儿比较，差异有显著性（P〈0．05）。结论：孕母患慢性淋巴细胞性甲状腺炎对婴儿甲状腺功能及智能发育有影响。

Effect of maternal autoimmune thyroid disease on intellectual development of infants

Objective: To study the effect of maternal Hashimoto's disease(an autoimmune thyroid disease) on intellectual development of infants.Methods: From July 2001 to June 2003,21 infants born by mothers suffered from Hashimoto's disease were followed up with provincial neonatal disease screening network system.Their thyroid function was assessed and their mental development was evaluated with Gesell development schedules.Results:(1) Among the 21 infants,8 showed normal thyroid function,11 showed hyperthyrotropinemia,2 cases had congenital hypothyroidism,which showed significant differences from those born by healthy mothers.(2) The mental and psychomotor development of infants whose mothers suffered from Hashimoto's disease lagged behind those with the healthy mothers(P<0.05).Conclusion: Maternal Hashimoto's disease may affects infants' thyroid function and mental development.