首页 | 本学科首页   官方微博 | 高级检索  
     


Results of unilateral adrenalectomy in subclinical Cushing's syndrome due to adrenocorticotropic hormone‐independent macronodular adrenal hyperplasia
Authors:Tetsuo Nozaki  Yasuhiro Iida  Akihiro Morii  Yasuyoshi Fujiuchi  Hikaru Suzuki  Mitsuyo Okazawa  Minoru Iwata  Hideki Fuse
Affiliation:1. Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, , Toyama, Japan;2. First Department of Medicine, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, , Toyama, Japan
Abstract:
Adrenocorticotropic hormone (ACTH)‐independent bilateral adrenocortical macronodular adrenocortical hyperplasia (AIMAH) is a rare cause of Cushing's syndrome (CS). Traditionally, bilateral adrenalectomy with subsequent lifetime steroid replacement has been considered to be the treatment of choice. In the present study, we evaluated the long‐term results of unilateral adrenalectomy in subclinical CS (SCS) due to AIMAH, with regard to the main laboratory and clinical abnormalities. Two patients with confirmed SCS due to AIMAH underwent unilateral laparoscopic adrenalectomy to reduce the cortisol‐secreting tissue. These procedures were successfully conducted in both cases without open conversion, and no surgery‐related morbidity occurred. In both cases, the size of the remaining adrenal gland appeared quite stable, and neither of the patients showed a Cushingoid appearance. Unilateral adrenalectomy achieved satisfactory and prolonged control of cortisol secretion, and also reduced the risk of metabolic disorders and cardiovascular disease after surgery. It can be a safe and effective treatment for SCS due to AIMAH, while maintaining the patient's quality of life.
Keywords:adrenocorticotropic hormone‐independent bilateral adrenocortical macronodular adrenocortical hyperplasia  laparoscopy  subclinical Cushing's syndrome  unilateral adrenalectomy
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号