慢加急性肝衰竭的预后评估及中西医结合治疗

慢加急性肝衰竭(ACLF)是在慢性肝病基础上,由各种诱因引起的以急性肝功能失代偿和短期高病死率为主要临床特征的一种可逆的、复杂的临床综合征。ACLF发病机制复杂,病情进展迅速,预后凶险,早期结局预测至关重要。目前,对于ACLF的治疗尚无理想的治疗手段,近些年来采用中西医结合治疗的方法取得了一定疗效。评述了ACLF预后评估及中西医结合治疗进展,旨在指导ACLF的预后判断及中西医结合治疗方案的选择。

Prediction of acute-on-chronic liver failure and integrated traditional Chinese and Western medicine therapy

Acute-on-chronic liver failure(ACLF) is a reversible and complex clinical syndrome caused by various factors in patients with pre-existing chronic liver diseases,with the clinical features of acute liver function decompensation and high short-term mortality rate.ACLF has a complex pathogenesis,rapid progression,and a dangerous prognosis,and early and accurate prediction of prognosis is of vital importance. At present,there is still no ideal therapy for ACLF,and in recent years,integrated traditional Chinese and Western medicine therapy has achieved a certain effect in the treatment of this disease. This article reviews the advances in prognostic evaluation and integrated traditional Chinese and Western medicine therapy for ACLF,in order to provide guidance to prognostic evaluation of ACLF and selection of the regimens of integrated traditional Chinese and Western medicine therapy.