| 异维A酸治疗播散性浅表性光线性汗孔角化症 |
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| 引用本文： | 邓婕,梁晓冬,叶瑞贤,刘焕颜,熊绮颖,田歆,张锡宝. 异维A酸治疗播散性浅表性光线性汗孔角化症[J]. 临床皮肤科杂志, 2020, 49(5): 283-285 |
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| 作者姓名： | 邓婕 梁晓冬 叶瑞贤 刘焕颜 熊绮颖 田歆 张锡宝 |
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| 作者单位： | 南方医科大学附属南海医院皮肤科,广东佛山528244;暨南大学附属顺德医院皮肤科,广东佛山528305;广州市皮肤病防治所皮肤科,广东广州510095 |
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| 摘 要： | 患者女,68岁。全身散在褐色角化性丘疹伴瘙痒2年余。皮损组织病理检查示角化过度,表皮增生,柱状角化不全,部分角化不全柱下可见部分角化不良细胞,真皮浅层片状淋巴细胞浸润。全基因组外显子测序提示患者MVK基因突变。诊断:播散性浅表性光线性汗孔角化症,治疗:口服异维A酸软胶囊、抗组胺药和外用维A酸药物3个月余,皮疹逐渐消退,瘙痒缓解,目前患者仍在随访中。
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| 关 键 词： | 汗孔角化症 异维A酸 治疗 |
A case of disseminated superficial actinic porokeratosis treated with isotretinoin |
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| DENG Jie,LIANG Xiao-dong,YE Rui-xian,LIU Huan-yan,XIONG Qi-ying,TIAN Xin,ZHANG Xi-bao. A case of disseminated superficial actinic porokeratosis treated with isotretinoin[J]. Journal of Clinical Dermatology, 2020, 49(5): 283-285 |
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| Authors: | DENG Jie LIANG Xiao-dong YE Rui-xian LIU Huan-yan XIONG Qi-ying TIAN Xin ZHANG Xi-bao |
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| Affiliation: | (Department of Dermatology,the Afilited Haspital of Southern Medical Universily,Foshan 528244,China) |
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| Abstract: | A 68-year-old woman had discrete brown keratinized papule with pruritus all over the body for more than 2 years. Histopathologic examination showed hyperkeratosis, epidermal hyperplasia, incomplete columnar keratinization, some keratinized cells with partial keratinization, and lamellar lymphocyte infiltration in superficial dermis. Genome-wide exome sequencing suggested MVK gene mutations. It was diagnosed as disseminated superficial actinic porokeratosis. After treatment of oral isotretinoin, antihistamine and external retinoic acid for more than 3 months, the skin lesions gradually subsided and the pruritus was under control. The patient is now being followed up. |
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| Keywords: | porokeratosis isotretinoin treatment |
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