普萘洛尔缓解单硝酸异山梨酯引起头痛的临床研究

目的观察普萘洛尔缓解单硝酸异山梨酯引起头痛的临床疗效。方法收集2017年10月至2018年10月在绵阳市中心医院心血管内科使用单硝酸异山梨酯引起头痛的62例患者,采用数字表法随机分为实验组和对照组各31例,实验组服用普萘洛尔,对照组服用维生素B₁。评估两组治疗前后头痛症状记分表、视觉模拟评分(VAS)、睡眠质量评分(QS)和TCD改善率和用药安全性。结果治疗过程中两组均无患者终止、脱落,均完成治疗。服用普萘洛尔的患者有效率(93.55%)显著高于对照组(77.42%),同时在起效及痊愈时间均明显较对照组缩短,差异均有统计学意义(均P<0.05)。在进行干预前两组受试者在头痛的VAS评分、发作频率、持续时间、睡眠质量及TCD方面差异均无统计学意义(均P>0.05);在干预后同一组受试者的VAS评分、发作频率、持续时间、睡眠质量及TCD均较治疗前显著改善,且实验组显著优于对照组,差异均有统计学意义(均P<0.05)。两组的不良反应发生率的差异无统计学意义(P>0.05);同时两组治疗期间均未发生明显的低血压、心力衰竭、畏寒、气管痉挛等不良反应。...

Clinical study of propranolol in relieving headache caused by isosorbide mononitrate

Objective To observe the clinical efficacy of propranolol in relieving headache caused by isosorbide mononitrate.Methods From October 2017 to October 2018,62 patients with headache caused by isosorbide mononitrate in Department of Cardiovascular in Mianyang Central Hospital were analyzed,these patients were randomly divided into the experimental group and the control group,31 cases in each group.The experimental group took propranolol while the control group took vitamin B1.The headache symptom scores table,visual analogue scale(VAS),quality of sleep(QS),TCD rating improvement rate,and medication safety evaluation were evaluated before and after treatment.Results During the treatment,no patients were terminated or detached in both groups,and the treatment was completed.The total effective rate of the observation group(93.55%)was significantly higher than that of the control group(77.42%).The onset time and recovery time were significantly shorter than the control group,and the difference was statistically significant(all P<0.05).Before treatment,there was no significant difference in VAS score,seizure frequency,duration,QS score and TCD between the two groups of subjects(all P>0.05).After treatment,in the same group the VAS score,seizure frequency,duration,QS score and TCD were significantly improved compared with before treatment,and the experimental group was significantly better than the control group,and the experimental group was significantly better than the control group,the difference was statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).There were no obvious adverse reactions such as hypotension,heart failure,chills and tracheal fistula during the treatment.Conclusion Propranolol can effectively relieve headache caused by isosorbide mononitrate.