非酒精性脂肪性肝病发生及进展的危险因素

非酒精性脂肪性肝病(NAFLD)的患病率逐年增加,目前成为我国成年人中最常见的慢性肝病之一。NAFLD可由非酒精性肝脂肪变性进展为非酒精性脂肪性肝炎、肝硬化、肝细胞癌及NAFLD相关性心血管事件、死亡等重大疾病。现对NAFLD发生的危险因素以及进展为肝纤维化、肝硬化、肝癌、相关心血管事件和死亡等重大疾病的相关危险因素进行综述,以便进一步探讨NAFLD发生发展的机制,降低NAFLD的患病率,减缓NAFLD的进展程度,降低相关疾病的病死率。

Risk factors for the development and progression of nonalcoholic fatty liver disease

The prevalence rate of nonalcoholic fatty liver disease (NAFLD) is increasing year by year, and at present, it has become one of the most common chronic liver diseases in adults in China. NAFLD can progress from nonalcoholic fatty degeneration of the liver to nonalcoholic steatohepatitis, liver cirrhosis, hepatocellular carcinoma, NAFLD-associated cardiovascular events, and death. This article reviews the risk factors for the development of NAFLD and the progression of NAFLD to major diseases such as liver fibrosis, liver cirrhosis, liver cancer, related cardiovascular events, and death, in order to further explore the mechanism of the development and progression of NAFLD, reduce the prevalence rate of NAFLD, slow down the progression of NAFLD, reduce the mortality rate of related diseases, and achieve better prevention and treatment.