Effects of CS-US interval on conditioning of drug response,with assessment of speed of conditioning

Summary Effects of CS-US interval on the development of a conditioned drug response was studied by pairing a 1.5 mg/kg ip d-amphetamine injection (US) with placement of S in a photocell-type locomotor activity cage (CS). Ss injected immediately before and 30 min before placement were significantly more active on saline-injection test days than were Ss injected after removal or 3–4 h later. To test for apparent rapid conditioning of drug response, Ss were given only six pairings with drug injection immediately preceding placement in the apparatus. On saline test day, these Ss were half again more active than controls, which had received saline just before placement and the drug 3–4 h later.This article is based upon a dissertation submitted by the senior author in partial fulfillment of the requirements for the Ph. D. degree at the University of Mississippi. Preparation of this article was supported in part by USPHS Training Grant No. MH-8565 to the University of Minnesota.