| 尖锐湿疣初发患者皮损中Livin和Caspase-3的表达 |
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| 引用本文： | 林丽,王军,秦晓明. 尖锐湿疣初发患者皮损中Livin和Caspase-3的表达[J]. 中国麻风皮肤病杂志, 2019, 35(6): 338-341. DOI: 10.12144/zgmfskin201906338 |
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| 作者姓名： | 林丽 王军 秦晓明 |
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| 作者单位： | 1皖南医学院第二附属医院皮肤性病科，安徽芜湖，2410012皖南医学院第一附属医院皮肤性病科，安徽芜湖，241001 |
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| 基金项目： | 皖南医学院重点科研项目培育基金(编号:WK2018ZF08) |
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| 摘 要： | 目的:检测尖锐湿疣(CA)初发患者皮损及正常包皮组织中Livin和Caspase-3的表达。方法:采用免疫组化法检测Livin和Caspase-3在30例CA初发患者皮损和20例正常包皮组织中的表达。结果:Livin和Caspase-3在CA组织的阳性表达率分别为76.67%和43.33%,在正常包皮组织表达率分别为25.00%和70.00%。Livin与Caspase-3在CA组织中的表达强度之间无相关性(r=0.238,P>0.05)。结论:在CA初发患者皮损中存在Livin高表达和Caspase-3低表达,二者可能共同参与了CA的发生与发展。
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| 关 键 词： | 尖锐湿疣 细胞凋亡 免疫组化 LIVIN CASPASE-3 |
Expression of Livin and Caspase-3 in the lesions of incipient condyloma acuminatum |
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| LIN Li,WANG Jun,QIN Xiaoming. Expression of Livin and Caspase-3 in the lesions of incipient condyloma acuminatum[J]. China Journal of Leprosy and Skin Diseases, 2019, 35(6): 338-341. DOI: 10.12144/zgmfskin201906338 |
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| Authors: | LIN Li WANG Jun QIN Xiaoming |
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| Affiliation: | 1.Department of Dermatology and STD,The Second Affiliated Hospital of Wannan Medical College，Wuhu 241001，China;2.Department of Dermatology and STD,The First Affiliated Hospital of Wannan Medical College，Wuhu 241001，China |
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| Abstract: | Objective: To determine the expression of Livin and Caspase-3 in the lesions of incipient condyloma acuminatum. Methods: The expression of Livin and Caspase-3 in the lesions of incipient condyloma acuminatum and normal prepuce tissues was detected by Streptavidin-peroxidase. Results: The positivity rates of Livin and Caspase-3 in the incipient condyloma acuminatum and normal prepuce were 76.67% and 43.33%, 25.00% and 70.00%. There was no correlation between the expression intensity of Livin and Caspase-3 in the incipient condyloma acuminatum group (r=0.238,P>0.05).Conclusion: There is high expression of Livin and low expression of Caspase-3 in the lesions of incipient condyloma acuminatum. Both may be involved in the development of condyloma acuminatum. |
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| Keywords: | condyloma acuminatum apoptosis Streptavidin-peroxidase Livin Caspase-3 |
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