The preliminary radiogenomics association between MR perfusion imaging parameters and genomic biomarkers,and their predictive performance of overall survival in patients with glioblastoma

Accumulating evidence has supported the role of microRNAs in the initiation and development of malignant tumors. MicroRNA-211 (miR-211), which was reported to involve in diverse physiological activities in several cancers, was investigated for its expression in human glioma and adjacent normal brain tissues, as well as its correlation with patient prognosis. Glioma tissues and adjacent normal brain tissues were obtained from 82 patients who underwent surgical resection, and quantitative real-time polymerase chain reaction was performed to assess the expression level of miR-211. Here, we found that miR-211 was significantly decreased in glioma tissues compared with adjacent normal brain tissues (glioma, 3.52?±?0.14 vs. normal, 4.96?±?0.17, p?p?p?=?0.026). Finally, the multivariate Cox regression analysis indicated that WHO grade (HR?=?2.437, 95% CI 1.251–4.966, p?=?0.007), KPS (HR?=?2.215, 95% CI 1.168–4.259, p?=?0.016), and miR-211 expression level (HR?=?3.614, 95% CI 2.152–6.748, p?