2005年～2006年我院常见病原菌耐药性分析

目的:调查分析益阳市中心医院临床分离常见病原菌对常用抗菌药物的耐药性状况,为合理利用抗生素控制感染提供依据。方法:采用Vitek-Ams和Kirby-Bauer法,检测常用抗菌药对临床分离革兰阴性杆菌和革兰阳性球菌的耐药性。结果:分离出1 280株菌株,位居前6位的分别为大肠埃希菌、金葡菌、肺炎克雷伯菌、铜绿假单胞菌、表皮葡萄球菌及白色念球菌,对抗生素耐药性检测结果显示,革兰阴性杆菌对美罗培南、哌拉西林/他唑巴坦最为敏感。革兰阳性球菌对万古霉素、美罗培南尚敏感。结论:开展细菌耐药性的监测对临床抗生素的合理使用,提高疗效,减少耐药菌株的发生有重要意义。

Analysis of Drug Resistance of Common Pathogenic Bacteria in Our Hospital During the Period 2005 ～ 2006

OBJECTIVE:To investigate the antibiotic resistance of common pathogenic bacteria isolated in the central hospital of yiyang for references of rational use of antibiotics in infection control.METHODS: Vitek-Ams system and Kirby-Bauer method were used to examine the antibiotic resistance of the clinically isolated G~-bacilli and G~+ cocci.RESULTS: 1 280 strains were isolated,dominating the first 6 places were escherichia coli,staphylococcus aureus,klebsiella pneumoniae,pseudomonas aeruginosa,staphylococcus epidermidis and blastomyces albicans in that order.The antibiotic resistance tests showed that G~-bacilli were most susceptible to meropenem and piperacillin sodium / tazobactam sodium,and G~+ cocci were susceptible to vancomycin and meropenem.CONCLUSION: Bacterial drug resistance monitoring is of great significance in the rational use of antibiotics,enhancing of drug efficacy and reduction of drug resistance.