The role of the complement system in innate immunity |
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Authors: | Horea Rus MD PhD Cornelia Cudrici Florin Niculescu |
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Institution: | (1) Department of Neurology, University of Maryland School of Medicine, 655 W Baltimore St, BRB 12-016, 21201 Baltimore, MD;(2) Multiple Sclerosis Center of Excellence, Veterans Administration Maryland Health Care System, 655 W Baltimore St, BRB 12-016, 21201 Baltimore, MD;(3) Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, 655 W Baltimore St, BRB 12-016, 21201 Baltimore, MD |
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Abstract: | Complement is a major component of innate immune system involved in defending against all the foreign pathogens through complement
fragments that participate in opsonization, chemotaxis, and activation of leukocytes and through cytolysis by C5b-9 membrane
attack complex. Bacterias and viruses have adapted in various ways to escape the complement activation, and they take advantage
of the complement system by using the host complement receptors to infect various cells. Complement activation also participates
in clearance of apoptotic cells and immune, complexes. Moreover at sublytic dose, C5b-9 was shown to promote cell survival.
Recently it was also recognized that complement plays a key role in adaptive immunity by modulating and modifying the T cell
responses. All these data suggest that complement activation constitutes a critical link between the innate and acquired immune
responses. |
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Keywords: | |
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