利培酮联合碳酸锂治疗躁狂的临床研究

目的 评价利培酮在躁狂发作治疗中的疗效及安全性.方法 选取70例患者随机分为利培酮组和氟哌啶醇组进行对照研究,两组均联用碳酸锂.采用Bech-Rafaelsen评定量表（BRMS）及其减分率对疗效进行观察,同时观察两组的锥体外系反应.结果 两组均从第2周开始起效,但从第4周开始利培酮组的减分率明显大于氟哌啶醇组,而且氟哌啶醇组联用抗霍奇金药的例数是氟哌啶醇组的2倍多.结论 利培酮不仅可以治疗躁狂,且具有相当高的安全性.

A controlled study of lithium carbonate with risperidone versus haloperidol in the treatment of mania

Objective To evaluate the efficacy and safety of risperidone in the mania. Methods Seventy patients with mania were randomly assigned into the treatment groups of risperidone or haloperidol for 4 weeks, two groups were buspironed with lithium carbonate BRMS and scores were used to measure their efficacy, and investigate EPS. Results Took effects after the treatment of 2 weeks in both groups, there was no significant difference. But total BRMS scale decreased significantly more in risperdone group than that in halopefidol group after the treatment of 4 weeks,and the prevalence of EPS in risperidone group was lower than that in haloperidol group. Conclusion Risperidone is an effective and safe drug in the treatment of mania,and continuely effective.