Two-week, but not 1-week, hypoxic exposure enhances nitric oxide-mediated basal tone regulation in rat resistance pulmonary arteries |
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| Authors: | Shirai M Shimouchi A Ikeda S Oya H Min K Y Kawaguchi A T Mori H Ninomiya I |
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| Affiliation: | National Cardiovascular Center Research Institute, Osaka, 565-8565 Japan. mshiraim@res.ncvc.go.jp |
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| Abstract: | We measured internal diameter (ID) changes in resistance and conduit pulmonary arteries of 1- and 2-week hypoxic rats and normoxic control rats in response to nitric oxide synthase (NOS) inhibitors in vivo. At 2 weeks of hypoxic exposure, the ID reduction as a result of NOS inhibition was enhanced within the resistance arteries, but not at 1 week of hypoxia. |
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