LINEAR GROWTH OF CHILDREN WITH LIMB DEFORMITIES FOLLOWING EXPOSURE TO THALIDOMIDE IN UTERO |
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| Authors: | C. G. D. BROOK S. N. JARVIS C. G. H. NEWMAN |
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| Affiliation: | The Departments of Paediatrics, The Middlesex Hospital, Wolf son Centre, Institute of Child Health and Westminster Hospital, London, England |
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| Abstract: | Abstract. The growth of 202 children exposed to thalidomide in utero and having upper (139 children) or lower (63 children) limb deformities has been assessed towards the end of pre-pubertal growth. The analyses show that children exposed to thalidomide are shorter than normal children but grow at a normal velocity later. These findings may help in consideration of the mechanism by which thalidomide exerted its teratogenic effect. Analyses of growth may find a wider use in the retrospective assessment of drugs which are potentially harmful in pregnancy. |
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| Keywords: | Thalidomide environmental teratogens growth limb deformities |
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