哮喘患儿生活质量与吸入糖皮质激素治疗的相关性分析

目的探讨吸入糖皮质激素(ICS)治疗哮喘对患儿生活质量、肺功能的改善情况与吸入治疗依从性的关系,并分析患儿不服从规范吸入治疗的原因。方法对具有应用ICS治疗指征并能完成填写儿科哮喘生存质量调查问卷(PAQLQ)和平行测量肺功能的83例患儿的资料作回顾分析,评估其生活质量、肺功能改善情况与吸入治疗依从性的关系。结果急性发作期,治疗组的FEV1(1秒钟用力呼气量)和PAQLQ评分均值在治疗前后有显著性差异(p<0.05);坚持治疗时间越长,改善越明显。对照组患儿在急性发作期治疗前后FEV1无改善(p>0.05),PAQLQ评分更低。治疗组与对照组的FEV1、PAQLQ评分均值都有显著性差异(p<0.05);非急性发作期,两组治疗前后的FEV1、PAQLQ评分均值无显著性差异(p>0.05)。结论坚持规范使用ICS治疗的哮喘患儿,其生活质量、肺功能改善比治疗不依从的患儿明显提高,发作时严重程度减轻。

RELEVANT ANALYSIS BETWEEN LIFE QUALITY AND INHALATION THERAPY WITH CORTICOSTEROID IN CHILDHOOD ASTHMA

Objective To investigate the relation between improvement in life quality,pulmonary function of asth-matic children and inhalation corticosteroid(ICS)therapy,and analyze the cause of incompliance to regular ICS.Methods Data of 83 asthmatic children with indication of ICS therapy and being able to complete the Pediatric Asthma Quality of Life Questionnaire(PAQLQ)and paralleling pulmonary function test were analyzed retrospectively,the relation between improvement of their life quality and pulmonary function and the ICS therapy were evaluated.Results During acute exacerbation,there was significant difference in FEV_1 and PAQLQ score before and after the ICS therapy in the therapy group(p<0.05)and the longer the inhalation therapy the greater the improvement was;while there wasn't significant difference in FEV_1 before and after the therapy in the control group(p<0.05),and the PAQLQ score was much lower in the control group.There was significant difference statistically in the FEV_1 and PAQLQ score between the two groups(p<0.05).During the course without acute exacerbation,there wasn't significant difference in FEV_1 and PAQLQ score before and after the ICS therapy between the two groups(p>0.05).Conclusion Improvement of life quality and pulmonary function of those compliance to regular ICS therapy is significantly greater than those of irregular inhalation therapy and severity of the exacerbation was less than those of irregular inhalation therapy group.