整合素-α2基因多态性与脑梗死发病的关系及其对脂代谢的影响

目的探讨整合素-α2（ITGA2）基因C807T多态性与脑梗死发病的关系及其对脂代谢的影响,研究急性脑梗死的发病机制。方法应用聚合酶链反应—限制性片段长度多态性（PCR-RFLP）方法检测脑梗死组及正常对照组的ITGA2基因型;同时按常规方法测定血浆脂质、脂蛋白水平。结果 ITGA2基因C807T多态性两组比较有统计学差异（P〈0.05）,T等位基因携带者患脑梗死的风险是C等位基因的1.635倍（OR=1.635,95%C：I 1.232－2.171）,携带T等位基因脑梗死患者的血清TC水平明显高于不携带者（P〈0.05）。结论 ITGA2基因C807T多态性与脑梗死发病有相关性,T等位基因可能是其发病的遗传易感基因;携带T等位基因的个体可能通过影响血脂水平而增加脑梗死的发病风险。

Relationship between integrin alpha-2 gene polymorphisms and cerebral infarction and its effect on plasma lipid levels

Objective To study the relationship between integrin alpha-2（ITGA2） gene C807T polymorphisms and cerebral infarction（CI） and the effect of integrin gene polymorphisms on plasma lipid on lipoprotein levels,and to analyze the nosogenesis of CI.Methods The polymorphism of ITGA2 gene was analyzed by the polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） method in patients with CI group and healthy controls.The plasma lipid and lipoprotein levels were measured by routine method.Results The distributions of ITGA2 gene C807T polymorphism was significantly different between CI group and control group（P〈0.05）,The relative risk suffered from CI of T allele was 1.635 times of the C allele（OR=1.635,95%CI：1.232～2.171）,The level of plasma lipid T allele carriers was significantly higher than that of no carriers（P,0.05）.Conclusions ITGA2 gene C807T polymorphism associates with CI,T allele carrier may be an increasing risk by affecting the levels of plasma lipid and lipoprotein of CI.