| 肾康丸对早期糖尿病肾病大鼠足细胞损伤的保护作用 |
| |
| 引用本文： | 龙海波,张辉,钟娟,朱艳,何井华,魏连波. 肾康丸对早期糖尿病肾病大鼠足细胞损伤的保护作用[J]. 南方医科大学学报, 2008, 28(7) |
| |
| 作者姓名： | 龙海波 张辉 钟娟 朱艳 何井华 魏连波 |
| |
| 作者单位： | 南方医科大学珠江医院中西医结合肾病中心,广东,广州,510282 |
| |
| 基金项目： | 南方医科大学校科研和教改项目 |
| |
| 摘 要： | 目的 观察肾康丸对糖尿病肾病(DN)大鼠肾小球足细胞形态及desmin、podocin表达的影响,探讨肾康丸对DN的肾保护作用机制.方法 应用链脲佐菌素建立大鼠DN模型,将DN模型大鼠随机分为4组:DN模型对照组、肾康丸组、厄贝沙坦组、肾康丸和厄贝沙坦合用组;另设正常对照组.各组分别干预8周后,观察24h尿蛋白定量变化,利用光镜、电镜观察肾脏病理改变,应用免疫组化技术观察足细胞desmin、podocin表达变化.结果 应用肾康九、厄贝沙坦干预后,DN大鼠24 h尿蛋白定量明显减少,肾脏病理改变显著减轻,足细胞desmin表达明显减少、podocin表达明显增加.结论 通过上调足细胞podocin的表达,使podocin的合成增加,从而减轻足细胞的损伤、维护足细胞结构和功能的完整性,可能是肾康丸对DN的肾保护作用机制之一.
|
| 关 键 词： | 糖尿病肾病 足细胞 肾康丸 厄贝沙坦 desmin podocin 肾康丸 期糖尿病 肾病大鼠 足细胞损伤 的保护 结构和功能 维护 合成 结果 表达变化 技术观 免疫组化 病理改变 肾脏 电镜观察 光镜 利用 尿蛋白定量 干预 组分 |
Protective effects of Shenkangwan against podocyte injury in rats with early diabetic nephropathy |
| |
| LONG Hai-bo,ZHANG Hui,ZHONG Juan,ZHU Yan,HE JING-hua,WEI Lian-bo Nephropathy Center of Integrated TCM , Western Medicine,Zhujiang Hospital,Southern Medical University,Guangzhou ,China. Protective effects of Shenkangwan against podocyte injury in rats with early diabetic nephropathy[J]. Journal of Southern Medical University, 2008, 28(7) |
| |
| Authors: | LONG Hai-bo ZHANG Hui ZHONG Juan ZHU Yan HE JING-hua WEI Lian-bo Nephropathy Center of Integrated TCM & Western Medicine Zhujiang Hospital Southern Medical University Guangzhou China |
| |
| Affiliation: | LONG Hai-bo,ZHANG Hui,ZHONG Juan,ZHU Yan,HE JING-hua,WEI Lian-bo Nephropathy Center of Integrated TCM & Western Medicine,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China |
| |
| Abstract: | Objective To investigate the morphological changes and expressions of desmin and podocin in podocytes of rats with diabetic nephropathy (DN) rats and renal protection mechanism of Shenkangwan. Methods DN model was established in rats by a single injection of streptozotocin. The rats were then randomly divided into model group, Shenkangwan treatment group, irbesartan treatment group, and Shenkangwan plus irbesartan treatment group, with normal rats as the control group. All the rats received daily gavage for... |
| |
| Keywords: | diabetic nephropathy podocytes Shenkangwan irbesartan desmin podocin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
