固肾胶囊治疗实验性大鼠糖尿病肾病的研究

目的：观察固肾胶囊对大鼠糖尿病肾病（DN）的治疗作用,方法：采用单侧肾切除加链脲佐菌素注射法复制DN大鼠模型,随机分为模型组,开达（开博通＋达美康）组,固肾胶囊大,小剂量组,灌胃给药8周后分别测定其对大鼠肾质量,肾功能及尿白蛋白排泄量的影响,结果：固肾胶囊大,小剂量组肾质量,肾质量／体质量比值,尿素氮,肌酐,尿蛋白排泄量均显低于模型组（P＜0．05或P＜0．01）,与开达组比较,各项指标差异无统计学意义,结论：固肾胶囊有抑制肾脏肥大,改善肾功能,减少尿蛋白的作用。

Study on Treatment of Gushen Capsule for Experimental Diabetic Nephropathy in Rats

Objective:To observe the therapeutic effects of Gushen capsule on diabetic nephropathy(DN) in rats. Method: After resection of one kidney and injection of streptozotocin (STZ), the DN rat model was established. Rats were randomly divided into 4 groups. Group 1 was model group, Group 2 was given kaibotong and diamicron by gastrogavage, Group 3 was given large dosage of Gushen capsule, Group 4 was given small dosage of Gushen capsule. After 8 weeks of administration, the weight of rat kidney, renal function and the excretion of urine albumin were measured. Result: The weight of kidney, weight of kidney/body weight ratio, blood urea nitrogen, creatinine and the excretion of urine albumin of Gushen capsule treated groups had a lower level than those of model group significantly. There was no significant difference between Gushen capsule treated groups and Group 2. Conclusion: Gushen capsule can not only inhibit the hypertrophy of kidney, but also improve renal function and reduce urine albumin.