可注射原位给药体系在蛋白类药物给药中的应用

可注射进入病灶部位并能原位给药的体系具有操作简单、局部给药、延长药物释放时间、减少用药剂量等诸多优点.近年来,各国研究者竞相研究可注射原位给药体系,并将其作为亲水性大分子药物尤其是蛋白类药物的药物载体.本文主要介绍了热塑性糊状体、原位交联聚合物体系、原位聚合物沉淀和热诱导凝胶体系四种缓释药物体系,着重讨论了将其作为蛋白类药物载体的优缺点.

Injectable in situ Forming Drug Delivery Systems for Protein

The ability to inject a drug incorporated into a polymer to a localized site and in situ to form drug delivery systems has a number of advantages, such as ease of application and location, prolonged drug delivery, and decreased body drug dosage. Recent years, increasing in situ forming drug delivery systems were developed to use in delivering hydrophilic model drugs, especially protein. This article outlined the various strategies used in in situ forming system, including thermoplastic pastes, in situ cross-linking polymer system, In situ polymer precipition, thermally induced gelation. The advantages and disadvantages as localized protein drug candidates were discussed as well.