CD1s在不同性别的1型糖尿病患者外周血单核细胞和淋巴细胞的表达

目的自身免疫疾病以女性发病多见,目前许多研究已表明CD1s与自身免疫性疾病有关。1型糖尿病是器官特异性自身免疫性疾病,本研究旨在探讨CD1s在1型糖尿病患者中的不同性别的表达差异。方法选取15～20岁的明确诊断为1型糖尿病的初发(病程小于6个月)患者24名(女10名,男14名),采用流式细胞术检测男女患者外周血单核细胞和淋巴细胞表面CD1分子的表达。结果 1型糖尿病女性患者的淋巴细胞表面CD1a、CD1c、CD1d的表达百分数显著高于男性患者。在单核细胞表面的表达未见明显差异(P>0.05)。结论不同性别的1型糖尿病患者其淋巴表面CD1s分子表达的不同,可能与CD1s识别不同的脂质抗原和雌激素有关,为1型糖尿病的防治提供了新的方向。

Expression of CD1 molecules in the peripheral monocytes and lymphocytes of type 1 diabetes patients of different genders

Objective Autoimmune diseases,more commonly seen in females than in males,are shown to be associated with CD1s by many researches.Our study aimed to explore the differential expressions of CD1s between different genders in patients with type 1 diabetes.Methods We detected the expression of CD1 molecules in the peripheral monocytes and lymphocytes by flow cytometry in 24 type 1 diabetes patients,including 14 boys and 10 girls aged 15-23 years,with the disease course <6 months.Results The surface expressions of CD1a,CD1c and CD1d in the lymphocytes were significantly higher in the female than in the male patients(P<0.05),but showed no significant difference in monocytes between the two groups(P>0.05).Conclusion The surface expressions of CD1s in the lymphocytes of type 1 diabetes patients are different between males and females,which gives rise to a hypothesis that different CD1s expressions may be associated with different lipidantigen and estrogen levels.This has offered a new insight into the prevention and individualized treatment of type 1 diabetes.