右美托咪定复合依托咪酯在无痛肠镜检查中的应用

目的观察右美托咪定复合依托咪酯用于无痛肠镜检查的临床效果及安全性。方法选择ASAⅠ～Ⅱ级无痛肠镜检查患者60例,随机分成两组(n=30):依托咪酯组(E组)、右美托咪定复合依托咪酯组(DE组)。DE组先0.1μg/(kg.min)静脉推注右美托咪定(0.1μg/kg),E组静脉推注安慰剂(0.9%生理盐水)3ml后,2min后两组再0.2mg/(kg.min)静脉依托咪酯(0.2mg/kg),完成后开始插镜,检查中如有体动反应,追加依托咪酯4～6mg,并观察依托咪酯总用量、可唤醒时间及体动,循环、呼吸抑制等不良反应。结果依托咪酯总用量、可唤醒时间E组明显高于DE组,差异有统计学意义(P<0.05);DE组体动发生例数明显低于E组,差异有统计学意义(P<0.05)。结论小剂量右美托咪定在无痛肠镜中的使用,方法简单,具有良好的安全性;能协同依托咪酯麻醉镇静作用,提供更佳的术中镇静效果。

Effect of Dexmedetomidine Combined with Etomidate Used on Painless Enteroscope

Objective A clinical study was conducted to investigate the safety and efficacy of dexmedetomidine(DEX) combined with etomidate for sedation of patients undergoing painless enteroscope.Methods Sixty patients with ASA Ⅰ-Ⅱ requiring enteroscope were randomized to received DEX 0.1μg/kg(group DE,n=30) or saline placebo(group E,n=30) as initial loading dose,followed by Eomidate 0.2mg/kg.Whether to add etomidate 4～6mg or not depended on the body activity and operation time.Waken time,operation time,the consumed dose of Etomidate were recorded.Results The body activity,the time of patient waken and the consumed dose of Etomidate were lower in group DE(P<0.05).Conclusion DEX combined with etomidate is efficent and safe for sedation of patients undergoing painless enteroscope.