中药复方S-抗毒合剂对小鼠单核巨噬系统吞噬功能和造血功能的作用研究

目的观察中药复方S-抗毒合剂对小鼠免疫和造血功能的影响.方法用 60Co照射和注射给予环磷酰胺的方法形成骨髓抑制和免疫低下小鼠模型,中药S-抗毒合剂口服给予,以外周白细胞、脾集落形成单位(spleencolony formed units, CFU-S)计数和碳廓清指数为观察指标.结果该药对环磷酰胺致小鼠外周血白细胞减少有明显提升作用;能促进 60Co照射小鼠骨髓有核细胞增殖及增加CFU-S;并能明显改善环磷酰胺所致小鼠的单核巨噬系统的吞噬功能低下.结论中药复方S-抗毒合剂有显著改善机体免疫功能和刺激骨髓造血功能的作用.

Effects of traditional Chinese medicine S-Kangdu mixture on phagocytosis and hematopoietic function of mononuclear macrophage system in mice

Objctive To study the effects of traditional Chinese medicine S Kangdu mixture on functions of immune system and bone marrow in mice. Methods Animal model, which marrow and immune system were inhibited, was established by 60 Co or cyclophosphamide injection. The mixture was administrated orally. The white blood cell counts, spleen colony formed unites (CFU S), and the index of carbon clean up were measured. Results The mixture obviously improved leukopenia in peripheral induced by cyclophosphamide administration, and facilitated marrow karyocyte proliferation and formation of CFU S in 60 Co treated mice and reinforced phagocytosis of mononuclear phagocytic system in cyclophosphamide treated mice. Conclusion Traditional Chinese medicine S Kangdu mixture can significantly ameliorate immunological function and stimulate hemopoietic function in mice.