多奈哌齐服药时间对阿尔茨海默病患者睡眠质量的影响

目的:观察多奈哌齐不同服药时间对阿尔茨海默病患者睡眠质量的影响,为该药的临床应用提供指导。方法:将2013年4月至2015年6月于我院就诊的150例伴有睡眠障碍的阿尔茨海默病患者作为研究对象,随机分为3组,每组各50例,A组服用加兰他敏,B组晚间服多奈哌齐,C组早晨服多奈哌齐。治疗8周后检测匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)、Epworth日间嗜睡量表指数。结果:经过治疗后,C组PSQI指数与A组、B组比较差异有统计学意义(t=12.14,32.50;P0.05);C组Epworth指数与A组、B组比较差异有统计学意义(t=5.59,16.22;P0.05),B组治疗前后PSQI指数、Epworth指数无差异(t=0.14,0.47;P0.05)。结论:在早晨服用多奈哌齐可以更好改善阿尔茨海默病患者的睡眠状态。

Effect of Donepezil Timingof Medication Administration on Sleep Quality of Patients with Alzheimer's Disease

Objective:Through the influence of observation of donepezil taking medicine at different time on quality of sleep in patients with Alzheimer's disease to provide guidance for the clinical application of the drug.Methods:The April 2013 to June 201 5 in our hospital,1 50 cases of sleep disorders associated with Alzheimer's patients as research subjects were randomly divided into three groups,each group 50 cases,group A taking galantamine,group B taking donepezil at night,group C taking donepezil in the moring.Detection Pittsburgh Sleep Quality Index(PSQI),Epworth index were tested after 8 weeks of treatment.Results:After treatment,the PSQI index of group C was significantly different with that of A group(t =12.14,P <0.05)and B group(t =32.50,P <0.05),and the Epworth index of group C was also different with that of group B(t =5.59,P <0.05)and group A(t =1 6.22,P <0.05).In group B,before and after treatment PSQI index,Epworth index had no difference(t =0.14,0.47;P >0.05 ).Conclusion:In the morning, taking donepezil may improve sleep better in Alzheimer's patients.