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Systemic lupus erythematosus associated with primary large cell carcinoma of the lung
Authors:Hidemi Irie  Hiroaki Satoh MD  Takao Akama  Yuko T Yamashita  Hiroichi Ishikawa  Morio Ohtsuka
Affiliation:(1) Department of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, 305-8575 Tsukuba City, Ibaraki, Japan;(2) Department of Rheumatology, Institute of Clinical Medicine, University of Tsukuba, Japan
Abstract:The association between systemic lupus erythematosus (SLE) and malignancy has been controversial in the literature. We report a case of lung cancer in a 50-year-old woman with a 4-year history of SLE. She underwent surgery at a pathological stage of T2N2M0, but she eventually died of rapid recurrence of the cancer in the abdomen resulting in massive haemorrhage from the inferior vena cava (IVC). Immunological disorders related to SLE are thought to contribute to rapid progression of the malignancy.
Keywords:systemic lupus erythematosus  lung cancer
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