慢性肝炎及肝硬化患者血小板计数的临床探讨

目的 探讨血小板计数(PLT)在慢性肝炎及不同程度肝硬化患者中的变化及临床意义.方法 采用日本Sysmex SF-3000全自动血细胞分析仪对慢性肝炎60例及肝硬化患者60例(按Child-Pugh分级:A级21例,B级22例,C级17例)、健康对照组100例的PLT进行检测,并将各组的变化进行比较分析.结果 慢性肝炎组和肝硬化组的PLT均显著减少(P＜0.01),随着肝硬化进程PLT减少更显著,与A级相比,B、C级的PLT更有显著变化(P＜0.01和P＜0.001).结论 外周PLT对评估慢性肝病的严重程度、出血倾向有重要的指导作用.

Investigation of clinical value of of platelet count in patients with chronic hepatitis and liver cirrhosis

Objective To investigate clinical significance of platelet count in patients with chronic hepatitis and liver cirrhosis.Methods Sixty patients with liver cirrhosis were graded as A(n=21),B(n=22)and C(n=17)according to Child-Pugh categories.Sysmex SF-3000 Auto Hematology Analyzer was applied to performing platelet count in 60 patients with chronic hepatitis,60 patients with liver cirrhosis and 100 healthy controls.Then the detective results were compared.Results PLT in chronic hepatitis group and liver cirrhosis group decreased significantly(P<0.01).In liver cirrhosis group,with the development of disease,the PLT count kept decreasing.The differences were more significant in B,C grade group than in A grade group.Conclusion Platelet count may be helpful to evaluate the severity and hemorrhage trend of chronic liver diseases.