普贝生用于足月羊水偏少引产的临床研究

【目的】观察普贝生用于足月羊水偏少引产的有效性、安全性。【方法】将120例孕37～41周未破膜，合并羊水偏少（B超示羊水指数5．0～8．0cm）单胎头位产妇随机分为普贝生组和缩宫素组各60例。普贝生组阴道后穹隆放置普贝生引产，缩宫素组常规静滴缩宫素引产，比较普贝生和缩宫素两种药物引产的宫颈Bishop评分、临产时间、分娩情况、阴道分娩率、产后出血、新生儿情况以及不良反应。【结果】普贝生组宫颈评分较宫缩素组显著提高（P〈0．01），普贝生组用药到临产时间明显短于缩宫素组（P〈0．01），普贝生组引产成功率高于缩宫素组。而产后出血及新生儿窒息率无显著差别。【结论】普贝生用于足月妊娠羊水偏少病例引产安全有效，能显著提高阴道分娩率，降低剖宫产率。

Clinical Observation of Propess for the Induction of Term Pregnancy with Oligohydramnios

[Objective]To observe the efficacy and safety of Propess for induction of term pregnancy with less amniotic fluid. [Methods]A total of 120 pregnant women with 37 to 41 weeks gestational age who suffered from oligohydraminios (amniotic fluid index was 5.0 to 8.0cm by B-mode ultrasonography) and carried singleton pregnancies in cephalic presentation with intact fetal membranes were divided into two groups. Experimental group (n=60) received a Propess inserted into posterior fornix for induction, while control group (60 cases) received intravenous drip of oxytocin. The cervical Bishop score, the time of labor starting, the progress of labor, vaginal delivery rate, postpartum hemorrhage, neonatal condition and adverse reaction were compared between the two groups. [Results] Compared to control group, the cervical Bishop score was significantly higher (P<0.01), the mean time to labor starting was significantly shorter (P<0.01) and the achievement ratio of vaginal delivery was higher in the experimental group. No significant differences were found in fetal distress or postpartum hemorrhage between the two groups. [Conclusion] Propess can be used for induction of oligohydraminios pregnancies in term effectively and safely. It can increase the vaginal delivery rate and decrease the uterine-incision delivery rate.