中心组合设计法优化黄连解毒黏附微球处方工艺

目的:确定黄连解毒黏附微球的最佳处方工艺。方法:以成品收率,小檗碱、栀子苷、黄芩苷包封率,微球在人工胃液中的黏度为指标,采用中心组合设计法优化黄连解毒黏附微球的处方工艺,对结果进行二项式拟合,对最优条件进行预测分析。结果:各指标二项式方程拟合度较好,按处方优化得到最佳条件制备黄连解毒黏附微球,各项指标与预测值接近。结论:中心组合设计法优化黏附微球工艺条件准确、可靠。

Optimization of Formulation of Huanglian-Jiedu Bioadhesive Microspheres by Central Composite Design

ObJective: To optimize the formulation of Huanglian-Jiedu bioadhesive microspheres. Method: The optimum formulation was investigated by central composite design with five responses ie. yield, entrapment efficiency of three effective ingredients and mucoadhesive property. The data were imitated using second-order polynomial equation, and the numerical optimization was performed. Result: Prepare microspheres with optimum formulation, and the responses approached the prediction at the optimum. Conclusion: The performulation and preparation of microspheres were reasonable and reliable.