复发性泌尿系结石患者24h尿枸橼酸盐含量的病例对照研究及结石成分分析

目的:分析复发性泌尿系结石患者尿枸橼酸排泄量与结石成分及微观形态,探讨泌尿系结石形成与复发的防治措施。方法:采用病例对照的研究方法,比较复发性泌尿系结石患者与对照组之间的尿枸橼酸排泄量,并运用红外光谱、X线衍射及扫描电镜分析复发性结石的成分与微观形态。结果:复发性结石患者尿枸橼酸排泄量显著低于对照组。结石的成分以草酸钙(80%)和尿酸结石(33%)为主。结论:结石患者术后的代谢分析、严格随访和适量的枸橼酸盐补充,可能在一定程度上降低泌尿系结石的复发率。泌尿系结石的成分分析可为制定预防结石复发方案提供理论依据。

Case-control study of 24-hour urinary citrate excretion in patients with recurrent urinary calculi and analysis of stone composition

Objective： To analyze 24-hour urinary citrate excretion and stone composition of recurrent urinary calculi patients. Method： The case-control study was conducted to compare 24-hour urinary eilrate excretion be- tween the recurrent urinary calculi patients and normal people who recovered from urinary calculi. ]nrared spec- troscopy, X-ray diffraction and scanning electron microscope were used for analyzing the micromorphology and composition of stones. Result： 24-hour urinary citrate excretion in patients with recurrent urinary calculi was sig- nificantly lower than normal people who recovered from urinary calculi, and the main composition were calcium ox- alate （809/0 ） and uric acid （33 ~ ）. Conclusion： Metabolism analysis, strict follow-up and appropriate supply of cit- rate may decrease the recurrence rate of urinary calculi. The result of composition of stones can be accepted as a theoretical base for preventive guidelines of urinary calculi.