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| 基质金属蛋白酶诱导因子和白三烯B4在急性冠状动脉综合征中表达 | |
| 引用本文： | 许莎莎,黄洁,江建军,王教辰,米亚非,刘志国,卢先本,薛迎生,葛卫力,王琳,陈保国,朱敏,黄维清,唐礼江. 基质金属蛋白酶诱导因子和白三烯B4在急性冠状动脉综合征中表达[J]. 临床心血管病杂志, 2011, 27(3) |
| 作者姓名： | 许莎莎 黄洁 江建军 王教辰 米亚非 刘志国 卢先本 薛迎生 葛卫力 王琳 陈保国 朱敏 黄维清 唐礼江 |
| 作者单位： | 1. 温州医学院附属台州医院心内科,浙江温州 2. 温州医学院附属台州医院病理科 3. 温州医学院附属台州医院中心实验室 4. 山东省青岛市市立医院东院病理科 |
| 基金项目： | 浙江省科技厅基金资助(No:2006c33019) |
| 摘 要： | 目的:研究基质金属蛋白酶诱导因子(EMMPRIN)及白三烯B4(LTB4)在急性冠状动脉综合征中表达。方法:设立稳定型心绞痛组(SAP组)、不稳定型心绞痛组(UAP组)、急性心肌梗死组(AMI组)及对照组(CON组),以流式细胞计数法测定患者外周静脉血单核细胞表面EMMPRIN表达,ELISA法检测其血清LTB4水平。结果:EMMPRIN在UAP组显著高于CON组、SAP组、AMI组,在UAP<1周亚组表达明显。LTB4在AMI组显著高于CON、SAP和UAP组,其AMI<24h亚组增高显著。结论:UAP患者外周血单核细胞表面EMMPRIN表达增高,其出现高峰为胸痛1周内;AMI患者血清中LTB4表达上调,高峰为胸痛24h之内。 |
| 关 键 词： | 急性冠状动脉综合征 细胞外基质金属蛋白酶诱导剂 白三烯B4 |
Expression of extracellularmatrix metalloproteinase inducer and leukotriene B4 in patient with acute coronary syndrome |
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| XU Shasha,HUANG Jie,JIANG Jianjun,WANG Jiaochen,MI Yafei,LIU Zhiguo,LU Xianben,XUE Yingsheng,GE Weili,WANG Lin,CHEN Baoguo,ZHU Min,HUANG Weiqing,TANG Lijiang. Expression of extracellularmatrix metalloproteinase inducer and leukotriene B4 in patient with acute coronary syndrome[J]. Journal of Clinical Cardiology, 2011, 27(3) | |
| Authors: | XU Shasha HUANG Jie JIANG Jianjun WANG Jiaochen MI Yafei LIU Zhiguo LU Xianben XUE Yingsheng GE Weili WANG Lin CHEN Baoguo ZHU Min HUANG Weiqing TANG Lijiang |
| Affiliation: | XU Shasha1 HUANG Jie1 JIANG Jianjun1 WANG Jiaochen2 MI Yafei1LIU Zhiguo1 LU Xianben1 XUE Yingsheng1 GE Weili1 WANG Lin1CHEN Baoguo3 ZHU Min3 HUANG Weiqing4 TANG Lijiang1(1Department of Cardiology,Taizhou Hospital,Wenzhou Medical College,Zhejiang 317000,china,2Department of Pathology,3Department of Center Lab,4Department of pathology,Qingdao Municipal Hospital) |
| Abstract: | Objective:To study the expression of extracellularmatrix metalloproteinase inducer(EMMPRIN) and leukotriene B4(LTB4) in patient with acute coronary syndrome(ACS).Method:There were four groups in this study,including SAP,UAP,AMI,and CON group.The expression of EMMPRIN on peripheral blood mononuclear cells were determined by flow cytometry,while LTB4 level in serum was measured by ELISA.Result:The expression of EMMPRIN in UAP patients was significantly higher than that in CON,SAP and AMI groups,especially in ... |
| Keywords: | acute coronary syndrome extracellularmatrix metalloproteinase inducer leukotriene B4 |
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