EFFECT OF NEOSTIGMINE AND PYRIDOSTIGMINE ON THE PLASMA CHOLINESTERASE ACTIVITY期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

EFFECT OF NEOSTIGMINE AND PYRIDOSTIGMINE ON THE PLASMA CHOLINESTERASE ACTIVITY

Authors:	BARAKA, A. MANSOUR, A. HADDAD, W. WAKID, N.

Affiliation:	Department of Anesthesiology, American University of Beiru Beiru Lebanon Department of Laboratory Medicine, American University of Beirut Beirut, Lebanon

Abstract:	The effect of neostigmine 0.05mg kg¹ or pyridostigmine0.25mg kg¹ on serum cholinesterase activity was investigatedin 20 adult patients undergoing elective surgery. Both drugsproduced marked depression of enzymatic activity. The maximaldepression was observed in samples taken 5mm after injection.The maximal percentage depression of enzymatic activity wasnot significantly different in the two drug groups. However,at 3060mm after injection, the degree of depression wasless in the neostigmine group. This may be attributed to thedifferent plasma clearances of neostigmine and pyridostigmine.

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