新生儿缺氧缺血性脑病患者血清可溶性细胞间黏附分子-1与超敏C反应蛋白浓度相关性研究

目的观察缺氧缺血性脑病（HIE）患者血清sICAM-1水平的同时，研究其与超敏c反应蛋白（hs—CRP）浓度的相关性，判断能否作为反映HIE患者病情变化及预后的指标。方法用免疫比浊法检测hs—CRP，ELISA法检测sICAM-1。结果与健康对照组比较，急性期HIE患儿血清hs—CRP、sICAM-1浓度明显增高，与健康对照组比较差异有统计学意义（P〈0．01）；恢复期hs—CRP、sI—CAM-1浓度明显下降，与健康对照组比较差异无统计学意义（P〉0．05）。结论血清sICAM—1和hs—CRP浓度均可作为反映HIE患者病情变化及预后的指标。

Correlation study on serum levels of slCAM-1 and hs-CRP in newborn infants with hypoxic-ischemie eneephalopathy

Objective To investigate the correlation of serum levels of soluble intercellular adhe-sion molecule-1(slCAM-1) and high-sensitivity C reactive protein (hs-CRP) in newborn infants with hypoxic-ischemie encephalopathy(HIE),as well as the clinical significance of the above two indicators in evaluating prognosis and pathogenetic condition, Methods Immunoturbidimetry(ITM) was applied to measuring hs-CRP,and enzyme linked immunosorbent assay(ELISA) was used to detect slCAM-1. Results As compared with those of healthy control group,the serum levels of hs-CRP and slCAM-1 were significantly increased in acute phase group(P＜0.01). However, the serum levels of hs-CRP and sICAM-1 were declined in recovery phase group. No statistical difference was found between recovery phase group and healthy control group(P>0.05). Conclusion Serum slCAM-1 and hs-CRP may be used as useful indicators of prognosis and pathogenetic condition.