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| 雪旺细胞源神经营养因子对神经元胆碱乙酰基转移酶活性的影响 | |
| 引用本文： | 李平,许扬滨,邬江,朱家恺,刘均墀. 雪旺细胞源神经营养因子对神经元胆碱乙酰基转移酶活性的影响[J]. 临床和实验医学杂志, 2007, 6(12): 4-5 |
| 作者姓名： | 李平 许扬滨 邬江 朱家恺 刘均墀 |
| 作者单位： | 中山大学附属第一医院,广东,广州,510080;中山大学附属第一医院,广东,广州,510080;中山大学附属第一医院,广东,广州,510080;中山大学附属第一医院,广东,广州,510080;中山大学附属第一医院,广东,广州,510080 |
| 基金项目： | 广东省自然博士启动基金,课题号04300360;广东省卫生厅基金,课题号A2004175. |
| 摘 要： | 目的研究雪旺细胞源神经营养因子(SDNF)是否影响运动神经元胆碱乙酰基转移酶(ChAT)活性,了解其对运动神经元功能的影响。方法SD大鼠制作成一侧面神经损伤模型,实验组局部应用雪旺细胞源神经营养因子,对照组应用磷酸盐缓冲液,连续21 d,采用免疫组化染色法研究损伤侧和实验侧面神经核中运动神经元ChAT活性改变。结果实验组中运动神经元的ChAT阳性细胞数,面积及灰度值均优于对照组(P<0.01)。结论外源性雪旺细胞源神经营养因子可以防止轴突损伤后运动神经元胆碱乙酰基转移酶活性的降低。 |
| 关 键 词： | 雪旺细胞源神经营养因子 胆碱乙酰基转移酶 面神经 |
| 修稿时间： | 2007-08-28 |
Effect of Schwann cells-derived neurotrophic factor on the activity of choline acetyltransferase of motoneurons |
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| LI Ping,XU Yang-bin,WU Jiang,et al.. Effect of Schwann cells-derived neurotrophic factor on the activity of choline acetyltransferase of motoneurons[J]. Journal of Clinical and Experimental Medicine, 2007, 6(12): 4-5 | |
| Authors: | LI Ping XU Yang-bin WU Jiang et al. |
| Affiliation: | LI Ping,XU Yang-bin,WU Jiang,et al.Department of Microsurgery,The First Affiliated Hospital of Sun Yat-sen UniversityT.Guangzhou Guangdong 510080,China. |
| Abstract: | Objective To study the effect of Schwann Cells-derived neurotrophic factor(SDNF)on the activity of choline acetyltransferase(ChAT) of motoneurons.Methods The right facial nerve of SD rats was transected.SDNF was applied for 7 days in experimental group while PBS was applied in control group.The number,area and gray degree value of ChAT positive cells were measured with immunohistochemistry assay.Results The number,area and gray degree values of ChAT positive cells increased significantly(P<0.01) compared with those in control group.Conclusion SDNF treatment may reverse the axotomy-induced ChAT activity decrease. |
| Keywords: | Schwann cells-derived neurotrophic factors(SDNF) Choline acetyltransferase(CHAT) Facial nerve |
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