Recent acute reduction in macrolide-resistant Mycoplasma pneumoniae infections among Japanese children |
| |
Authors: | Yoshitaka Nakamura Tomohiro Oishi Kazunari Kaneko Tsuyoshi Kenri Takaaki Tanaka Shoko Wakabayashi Mina Kono Sahoko Ono Atsushi Kato Eisuke Kondo Yuhei Tanaka Hideto Teranishi Hiroto Akaike Ippei Miyata Satoko Ogita Naoki Ohno Takashi Nakano Kazunobu Ouchi |
| |
Institution: | 1. Department of Pediatrics, Kansai Medical School, Osaka, Japan;2. Department of Pediatrics, Kawasaki Medical School, Okayama, Japan;3. Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo, Japan;4. Department of Pediatrics, Aso Iizuka Hospital, Fukuoka, Japan |
| |
Abstract: | IntroductionMycoplasma pneumoniae contributes to numerous pneumonia cases among children and young adults. Therefore, this study aimed to investigate the prevalence of M. pneumoniae infections among Japanese children, occurring since 2008.MethodsNasopharyngeal swab specimens were obtained from all cases, following which real-time PCR was performed to identify M. pneumoniae. Further, the p1 genotypes of isolates were determined using the PCR restriction fragment length polymorphism typing method.ResultsThe annual rate of macrolide-resistant M. pneumoniae (MRMP) infections peaked at 81.8% in 2012 and decreased annually until 2015. Although the infection rate increased to 65.3% in 2016, it decreased again to 14.3% in 2018. Although >90% of isolates harbored the type 1 genotype until 2012, this rate decreased, and approximately 80% harbored p1 genotypes other than type 1 in 2018. Furthermore, the occurrence rate of MRMP among the type 1 isolates was very high (82.4%), whereas that among p1 genotypes other than type 1 was very low (6.5%).ConclusionsMRMP occurrence potentially decreased owing to changes in not only antibiotic usage but also in the distribution of p1 genotype among isolates. |
| |
Keywords: | Pediatric cases Japan Respiratory tract PCR-RFLP"} {"#name":"keyword" "$":{"id":"kwrd0040"} "$$":[{"#name":"text" "_":"PCR restriction fragment length polymorphism MR"} {"#name":"keyword" "$":{"id":"kwrd0050"} "$$":[{"#name":"text" "_":"macrolide resistance MP"} {"#name":"keyword" "$":{"id":"kwrd0060"} "$$":[{"#name":"text" "$$":[{"#name":"italic" "_":"Mycoplasma pneumoniae MRMP"} {"#name":"keyword" "$":{"id":"kwrd0070"} "$$":[{"#name":"text" "_":"macrolide resistance mycoplasma pneumoniae PPLO"} {"#name":"keyword" "$":{"id":"kwrd0080"} "$$":[{"#name":"text" "_":"pleuropneumonia-like organisms |
本文献已被 ScienceDirect 等数据库收录! |
|