Redevelopment after spontaneous sputum conversion in noncavitary nodular bronchiectatic Mycobacterium avium complex lung disease |
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| Authors: | Ock-Hwa Kim Yong pil Chong Tae Sun Shim Kyung-Wook Jo |
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| Affiliation: | 1. Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Chungnam National University Sejong Hospital, Sejong, South Korea;2. Department of Infectious Diseases, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea;3. Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea;1. Department of General Pediatrics, Tokyo Metropolitan Children’s Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan;2. Clinical Research Support Center, Tokyo Metropolitan Children’s Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan;3. Department of Pediatrics, Tama-Hokubu Medical Center, Tokyo Metropolitan Health and Medical Treatment Corporation, 1 Chome-7-1 Aobacho, Higashimurayama, Tokyo, 189-8511, Japan;1. FALCO Biosystems K. K., Tokai Central Laboratory, Test Group Microbiology, Aichi, Japan;2. Beckman Coulter K. K., Tokyo, Japan;3. FALCO Biosystems K. K., Okayama Laboratory, Test Group Microbiology, Okayama, Japan;4. Department of Clinical Laboratory Science, Faculty of Health Care, Tenri Health Care University, Japan;1. Division of Infectious Diseases, Department of Health Sciences (DiSSal), San Martino Hospital and IRCCS, University of Genoa, Genoa, Italy;2. Centro Ortopedico di Quadrante and Madonna Del Popolo Hospital, Omegna, VB, Italy;3. Public Health Department, Santa Maria Delle Croci Hospital, Ravenna, AUSL Romagna, Italy;4. Infectious Diseases SOC, A.S.O. SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy;5. Infectious Diseases Unit, Sant’Andrea Hospital, Vercelli, Italy;1. Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan;2. Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan;3. Department of Hematology, Iwate Prefectural Central Hospital, Iwate, Japan;1. Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea;2. Seoul Clinical Laboratories Academy, Yongin, 16954, South Korea |
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| Abstract: | ![]()
BackgroundAlthough spontaneous sputum conversion can occur in noncavitary nodular bronchiectatic (NC-NB) Mycobacterium avium complex lung disease (MAC-LD), little is known about redevelopment after spontaneous conversion. We investigated the redevelopment phenomenon after spontaneous sputum conversion in patients with NC-NB MAC-LD.Material and methodsAmong patients diagnosed with NC-NB MAC-LD between 2000 and 2013, 140 patients who experienced spontaneous sputum conversion, and whose follow-up duration after conversion was ≥6 months, were enrolled at a tertiary referral center in South Korea. Their medical records were retrospectively reviewed.ResultsOf the 140 patients, 34 (24.3%) underwent redevelopment during the median follow-up period of 71.0 months (interquartile range [IQR], 58.8–87.5). Redevelopment occurred at a median interval of 25.0 months (IQR, 11.5–41.8) after spontaneous sputum conversion. The mean age of the 34 patients with redevelopment was 63.6 years, and 73.5% were women. No statistically significant differences in clinical characteristics were noted between the 34 patients with redevelopment and those with persistent conversion. Among the 34 patients with redevelopment, 6 received treatment at a median interval of 8 months (IQR, 1.5–16.8) after redevelopment. No significant differences in clinical characteristics were noted between the six treated and 28 untreated patients.ConclusionAt least approximately 24% of patients with spontaneous sputum conversion in NC-NB MAC-LD had redevelopment, and a portion of them required treatment. These findings suggest that long-term follow-up is necessary for patients with NC-NB MAC-LD, even those who experience spontaneous sputum conversion. |
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| Keywords: | Spontaneous sputum conversion Redevelopment NTM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0030" }," $$" :[{" #name" :" text" ," _" :" nontuberculous mycobacteria LD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" lung disease MAC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" italic" ," _" :" Mycobacterium avium" },{" #name" :" __text__" ," _" :" complex FC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" fibrocavitary NB" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" nodular bronchiectatic CNB" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" cavitary nodular bronchiectatic NC-NB" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" non-cavitary nodular bronchiectatic AFB" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" acid-fast bacillus MIC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" minimal inhibitory concentration IQR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" interquartile range MABC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" italic" ," _" :" Mycobacterium abscessus" },{" #name" :" __text__" ," _" :" complex |
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