Inhibitors for the mutagenicities of colon carcinogens, 1,2-dimethylhydrazine and azoxymethane, in the host-mediated assay. |
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| Authors: | M Moriya T Ohta K Watanabe Y Watanabe F Sugiyama T Miyazawa Y Shirasu |
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| Institution: | Toxicology Division, Institute of Environmental Toxicology, Suzuki-cho 2-772, Kodaira-shi, Tokyo 187 (Japan) |
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| Abstract: | Inhibitory effects of several chemicals on the mutagenicities of 1,2-dimethylhydrazine (DMH) and azoxymethane (AOM) for Salmonella typhimurium G46 in the host-mediated assay were investigated. They were carbon disulfide (CS2), tetraethylthiuram disulfide (disulfiram, DSF), sodium diethyldithiocarbamate (SDDC), ethylene-bis(dithiocarbamato) manganese (Maneb), pyrazole (PZ), aminoacetonitrile hydrogen sulfate (AAN), and sodium selenite (SE). All the compounds, except for SE, inhibited the mutagenicities of DMH and AOM. |
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| Keywords: | AAN aminoacetonitrile hydrogen sulfate AM azomethane AOM azoxymethane DMH 1 2-dimethylhydrazine DSF tetraethylthiuram disulfide MAM methylazoxymethanol PZ pyrazole SDDC sodium diethyldithiocarbamate SE sodium selenite |
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