333例肺结核病患者不规则治疗原因与转归分析

目的了解肺结核病患者不规则治疗的原因和转归,探讨提高病人治疗的依从性和治愈率。方法比较上海市2001—2003年333例不规则治疗肺结核病患者的性别、年龄,对不规则治疗原因进行排序分析。结果不规则治疗的肺结核病患者与同期新登记结核病人性别比男性多于女性(χ²=12.5,P<0.001);不规则治疗原因中以药物不良反应(64.3%)及不配合(26.7%)为主;初治菌阳病人治愈率略高于复治菌阳病人治愈率(χ²=0.077,P>0.05)。结论采用合理的化疗方案,加强对重点病例(尤其是男性、高龄、菌阳病人)的督导管理,妥善处理药物不良反应,将减少病人的不规则治疗率,提高肺结核病例的治愈率。

Analysis on causes and outcomes of irregular treatment of 333 pulmonary tuberculosis patients

Objective To find out the causes and outcomes of irregular treatment of pulmonary tuberculosis cases,and to discuss the Methods to improve the compliance and increased cure rate. Methods The sex and age of 333 pulmonary tuberculosis cases with irregular treatment during 2001 to 2003 in Shanghai were compared and the causes of irregular treatment were analyzed. Result The male pulmonary tuberculosis cases of irregular treatment are higher than female cases(χ²=12.5,P<0.001).The causes of irregular treatment mainly include adverse drug effects(64.3%) and noncooperation(26.7%).The cure rate of new smear positive cases was slightly higher than retreatment smear positive cases.(χ²=0.077,P>0.05). Conclusion To reduce the irregular treatment and increase cure rate,the reasonable treatment regimen should be used,supervision and management to the priority cases(male,old,smear positive) should be strengthened and the adverse drug effects should be managed properly.