干细胞治疗炎症性肠病的安全性及有效性

炎症性肠病(inflammatory bowel disease，IBD)是一组以复杂的病因和病理生理学改变为基础的疾病，涉及肠道微生物的改变、异常免疫反应、肠上皮细胞和血管系统提供的重要屏障的破坏，并且是一种难以治愈的疾病。药物治疗及手术切除等传统治疗方式存在明显的不足。近年干细胞因其生物学特性开辟了治疗IBD的新型方法。本文就传统方式治疗IBD的不足进行概括，并对干细胞尤其是间充质干细胞移植治疗IBD的安全性、有效性文献进行了回顾总结。

Safety and efficacy of stem cell therapy for inflammatory bowel disease

Inflammatory bowel disease(IBD)is a group of diseases on the basis of complex etiology and pathophysiology changes involving the changes of intestinal microflora, abnormal immune response, damage of important barrier offered by intestinal epithelial cells and vascular system, and is a kind of incurable disease.There are obvious deficiencies in traditional treatment, such as drug treatment and surgical excision.In recent years, stem cells have opened up a new method for the treatment of IBD because of their biological characteristics.This review summarizes the shortcomings of traditional treatment for IBD, and analyzes the safety and efficacy that stem cells transplantation treats IBD, especially mesenchymal stem cells.