真实世界研究在骨关节炎临床实践指南制定中的作用与思考

真实世界研究正在成为医疗卫生领域关注的重点，尤其是其对于临床决策的作用和意义。在已发布的几部骨关节炎临床实践指南中，针对同一临床问题的推荐意见等级存在差别。这种差异可能与证据的来源以及评价方法有关。传统临床随机对照试验由于研究对象在选择方面的限制可能导致无法将研究结果从部分推广到整体。为了阐释真实世界研究的概念以及说明真实世界研究在临床实践指南制定方面的作用，本综述以现有的骨关节炎临床实践指南为例，对真实世界研究的一些重要内容概述并对其在指南制定中发挥的可能作用进行探讨，以期为未来的临床实践指南制定提供理论指导。

Real-world research in developing clinical practice guidelines for osteoarthritis

Real world research is becoming the focus in the field of health care, especially its role in clinical decision-making. In several published clinical practice guidelines for osteoarthritis, there are differences in the levels of recommendation for the same intervention. These discrepancies may be related to the source of the evidence. The present study briefly reviewed the clinical practice guidelines for osteoarthritis to explain the definition of real-world research and its role in developing clinical practice guidelines. The purpose of the present study is to provide theoretical guidance for future clinical practice guidelines.