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| 电刺激大鼠黑质网状部对脚桥核神经元自发放电的影响 | |
| 引用本文： | 郑贺,林宇涵,李靖远,高东明. 电刺激大鼠黑质网状部对脚桥核神经元自发放电的影响[J]. 神经解剖学杂志, 2011, 27(1): 39-43 |
| 作者姓名： | 郑贺 林宇涵 李靖远 高东明 |
| 作者单位： | 辽宁医学院生理学教研室,锦州,121000 |
| 基金项目： | 辽宁省科技厅科学技术计划项目(2009225010-48) |
| 摘 要： | 目的:观察电刺激大鼠黑质网状部(substantia nigra pars reticulata,SNr)对脚桥核(pedunculopontine nucleus,PPN)神经元自发放电活动的影响,进一步探讨脑内电刺激治疗帕金森病(Parkinson's disease,PD)的机制.方法:应用细胞外记录方法观察不同... |
| 关 键 词： | 脚桥核 黑质网状部 电刺激 帕金森病 |
Effect of electrical stimulation of the substantia nigra pars reticulata on the neuronal activities of pedunculopontine nucleus in rats |
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| Zheng He,Lin Yuhan,Li Jingyuan,Gao Dongming. Effect of electrical stimulation of the substantia nigra pars reticulata on the neuronal activities of pedunculopontine nucleus in rats[J]. Chinese Journal of Neuroanatomy, 2011, 27(1): 39-43 | |
| Authors: | Zheng He Lin Yuhan Li Jingyuan Gao Dongming |
| Affiliation: | Zheng He,Lin Yuhan,Li Jingyuan,Gao Dongming(Department of Physiology,Liaoning Medical College,Jinzhou 121000,China) |
| Abstract: | Objective:To study the effect of electrical stimulation of the substantia nigra pars reticulate(SNr) on the neuronal activities of pedunculopontine nucleus(PPN)in rats,furthering the mechanism of deep brain stimulation in the treatment of Parkinson's disease.Methods:Electrophysiological recordings were made in anaesthetized rats to investigate the effects of SNr electrical stimulation with different frequencies on the firing rate of the PPN neurons.Results:For SNr stimulation at low frequency(5-10 Hz),there... |
| Keywords: | pedunculopontine nucleus substantia nigra pars reticulata electrical stimulation Parkinson's disease |
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