The relationship between features of metabolic syndrome and blood adipocytokine concentrations in the morbid obese patients during dynamic weight loss |
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Authors: | Joanna Jankiewicz-Wika Krzysztof Kołomecki Jacek Cywiński Katarzyna Piestrzeniewicz Henryk Stępień Jan Komorowski |
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Institution: | (1) Department of Endocrinology, Medical University of Łódź, 91-425 cŁódź, Poland;(2) Department of General Surgery, Ministry of the Interior Hospital, 91-425 Łódź, Poland;(3) Department of Cardiology, Medical University of Łódź, 91-425 Łódź, Poland |
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Abstract: | Bariatric surgery is the most effective method to achieve weight loss in obese subjects.
The aim of this study was to evaluate some adipocytokines and insulin, as well as parameters of metabolic syndrome of the
obese patients, for three and six months after vertical banded gastroplasty, in the time of dynamic weight loss.
Seven males and two females aged 28 to 49 years, with long lasting simple obesity and the presence of metabolic syndrome,
were studied. After surgical treatment the values of the body mass index, waist circumference, systolic and diastolic blood
pressure, total cholesterol, LDL cholesterol, triglycerides, and blood concentrations of leptin decreased significantly.
Before surgical operation of all obese patients no statistically significant correlations between studied parameters were
noted. Three and six months later a lot of correlations between studied parameters appeared.
In conclusion, (a) vertical-banded gastroplasty is a valuable method in treatment of obese subjects, leading to a significant
decrease in body weight and improvement in some parameters of metabolic syndrome in a few months after surgery, (b) adipocytokines,
together with an unknown gastric factor, may be key factors in the control of some features of the metabolic syndrome. |
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Keywords: | Obesity metabolic syndrome adiponectin leptin resistin |
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